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  • br The proposed research su ciently compared and promoted

    2019-10-02


    The proposed research su ciently compared and promoted un-derstanding of typical online learning algorithms. Complicated pa-rameter tuning is one of the main concerns in improving online learning performances. The GAOGB algorithm addresses issues of parameter selection, conforms to certain convergence bounds and maintains su cient adaptiveness. The experimental results suggest that the GAOGB structure is effectively configured. In addition, this AUY922 (NVP-AUY922) research validates that parameter tuning is a critical step in online learning algorithms.
    The future work is discussed from two aspects: the BC research and online boosting. Most current BC research topics focus on of-fline and supervised learning, requiring long retraining time and massive manual labeling work. Online learning models are recom-mended for more BC research topics, and label-free learning tech-niques show promise in saving human labor. For online boosting, enhancing the superiority of GAOGB over OGB is an interesting challenge, which may be tackled through adapting a heuristic al-gorithm for online parameter optimization in a more e cient way. From another perspective, configuring effective parameter free al-gorithms is also a promising direction.
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    Contents lists available at ScienceDirect
    Cancer Letters
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    Original Articles
    A feedforward relationship between active Rac1 and phosphorylated Bcl-2 is T critical for sustaining Bcl-2 phosphorylation and promoting cancer progression
    Stephen Jun Fei Chonga,b, Jolin Xiao Hui Laia, Jianhua Qua,b, Jayshree Hirparad, Jia Kanga,c, Kunchithapadam Swaminathane, Thomas Lohf, Ansu Kumarg, Shireen Valih, Taher Abbasih, Shazib Pervaiza,b,c,i,∗ a Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore b Medical Science Cluster Cancer Program, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore