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Diabetes & Metabolic Syndrome: Clinical Research & Reviews
Adipocytokines, inflammatory, epigenetic instability & angiogenesis biomarkers in type 2 diabetic Egyptian women with breast cancer
Heba Bassiony Ghanem a, *, Mohammed Elsheikh b, Sanaa Ali El-Benhawy c, Abeer Shahba d
a Medical Biochemistry Department, Faculty of Medicine, Tanta University, El-Geesh Street, Tanta, Egypt
b General Surgery Department, Faculty of Medicine, Tanta University, El-Geesh Street, Tanta, Egypt
c Radiation Sciences Department, Medical Research Institute, Alexandria University, Alexandria, Egypt
d Internal Medicine Department, Faculty of Medicine, Tanta University, El-Geesh Street, Tanta, Egypt
Fatty acid-binding proteins-4
8-Hydroxy- 20-deoxyguanosine Vascular endothelial growth factor Tumor necrosis factor-a Thioredoxin reductase
Obesity is the main determinant of type 2 diabetes. Some adipocytokines play important roles in diabetic complications. Lipid transport is an important aspect of lipid metabolism in cancer. Present study aimed to evaluate the effect of some adipocytokines, inflammatory, epigenetic insta-bility & angiogenesis biomarkers in type 2 diabetic Egyptian women with breast cancer. Study Design was performed on eighty females divided into 20 healthy subjects (Group I), 20 patients with type 2 diabetes (Group II), 20 patients with breast cancer (Group III) & 20 patients with diabetes and breast cancer (Group IV). Demographic data & body mass index have been collected. Biochemical analysis included fasting & postprandial blood glucose, lipid profile, fatty acid-binding proteins-4 (FABP-4), tumor necrosis factor-a (TNF-a), vascular endothelial growth factor (VEGF), 8-hydroxy-20-deoxy-guanosine (8-OHdG) & thioredoxin reductase (TrxR) activity.
Results revealed significant increase in FABP-4, TNF-a, VEGF, 8-OHdG and significant decreased TrxR activity in diabetic patients with breast cancer in comparison with other groups. These changes were evident in breast cancer subjects than diabetic and healthy cases and in diabetic than healthy cases.
Conclusion: This study confirmed the role of FABP-4 in pathogenesis of type 2 diabetes & breast cancer via enhancing angiogenesis, inflammatory and epigenetic instability biomarkers. © 2018 Diabetes India. Published by Elsevier Ltd. All rights reserved.
The balance in the lipid and carbohydrate metabolism is altered by environmental or metabolic stress, lifestyle, genetic or epige-netic factors, they can also become critical components of patho-physiological cascades that are highly damaging, leading to organelle dysfunction, chronic inflammation & cell death .
Obesity which is the main determinant of type 2 diabetes , leads to a local lipotoxic environment through dysregulated release of fatty acids, leading to an immune phenotype of adipose tissue characterized by increased release of cytokines such as Tumor ne-crosis factor-a (TNF-a) .
TNF-a are considered to be the main regulators of inflammatory cytokines in diabetes .
* Corresponding author.
E-mail address: [email protected] (H.B. Ghanem).